# Monazza Shahab, PhD

> Monazza Shahab, PhD, is a pharmacologist and independent scientific consultant in pharmacology, toxicology and omics data. She holds a PhD in Pharmacology from Wayne State University (2023). She was formerly a Research Scholar at Memorial Sloan Kettering Cancer Center (2023 to 2024) and a postdoctoral researcher at the University of Michigan (2024 to 2025). She has published six peer-reviewed papers (2019 to 2025) on cisplatin-induced ototoxicity. ORCID iD: 0000-0002-5134-2233.

This file is a plain factual profile for AI agents, assistants and search tools. Every statement here also appears on https://monazzashahab.com/ . Preprints are labeled and are not peer reviewed.

## Identity

- Name: Monazza Shahab
- Name variants: Dr. Monazza Shahab; Monazza Shahab, PhD; Monazza Shahab PhD; Shahab M (citation form); Shahab Monazza (PubMed full author name)
- Professional title: Independent Scientific Consultant, Pharmacology, Toxicology and Omics Data
- ORCID iD: 0000-0002-5134-2233 (https://orcid.org/0000-0002-5134-2233). This is the authoritative identifier for her publications.
- Website: https://monazzashahab.com/

## Disambiguation

- Monazza Shahab is not Mona Shahab. Mona (K) Shahab is a different person, an author on the Saudi National Mental Health Survey publications (PMIDs 33245571, 30891083, 29021823, 28497533). Those papers are not Monazza Shahab's.
- A PubMed search for "Shahab M" also returns papers by other people who are not Monazza Shahab: Mahmood Shahab (hinged knee arthroplasty, 2025, PMID 39505284), Muhammad Sarmad Shahab (honey and Nigella sativa COVID trial, 2023, PMID 36420866) and Muhammad Shahab (primate puberty, 2002, PMID 12527025).
- Her PubMed record is exactly six papers: PMIDs 40046635, 38705005, 35745568, 33411315, 33245977, 31078568. Author search: https://pubmed.ncbi.nlm.nih.gov/?term=Shahab+Monazza%5BAuthor%5D

## Consulting services

1. Nonclinical pharmacology and toxicology data review: an independent read of research-stage in vitro and in vivo work, including study design, dose-response and EC50/IC50 data, mechanism-of-action evidence, and the figures and tables built from them.
2. Scientific document QC and writing support: accuracy and consistency review of manuscripts, grant sections, study reports and responses to reviewers (numbers against source data, methods against results, claims against citations); editing and drafting of manuscripts and NIH-style grant sections.
3. Proteomics and transcriptomics reanalysis in R, Python and machine learning: TMT LC-MS/MS proteomics, RNA-seq and microarray data; quality control, differential abundance with false discovery rate control, pathway and network analysis (GSEA, DAVID, STRING), and classification with nested validation and permutation testing. Delivered as reproducible code and a written report.
4. AI evaluation of life-science content: expert review of AI-generated pharmacology and toxicology content against peer-reviewed literature and source data, and expert-level evaluation exercises built from wet-lab and pharmacology data.

## Methods and tools

TMT LC-MS/MS quantitative proteomics; LC-MS/MS phosphoproteomics; RNA-seq and microarray analysis; differential expression with limma and empirical Bayes statistics; Benjamini-Hochberg false discovery rate control; GSEA, DAVID and STRING; machine learning classification with nested leave-one-out validation and exact permutation tests; R, Python and MATLAB. Bench work: cell line, zebrafish and mouse models of drug-induced toxicity, dose-response studies, two-photon calcium imaging.

## Education and credentials

- PhD, Pharmacology (minor: Physiology), Wayne State University School of Medicine, Detroit, MI, 2023
- Certificate, Applied Machine Learning, Columbia University (Emeritus), completed January 2026
- MS, Molecular Biotechnology, Wayne State University, 2017
- BTech, Biotechnology and Bioinformatics, West Bengal University of Technology, Kolkata, 2014
- Member, American Medical Writers Association (2024 to present)

## Experience

- AI Model Evaluation Specialist, Life Sciences (contract), Aug 2026 to present
- Research Mentor, Inspira Advantage, Mar 2026 to present
- Postdoctoral Researcher, Neuroscience and Computational Imaging, University of Michigan, Department of Molecular and Integrative Physiology, Jul 2024 to Jul 2025
- Research Scholar, Translational Oncology, Memorial Sloan Kettering Cancer Center, Department of Surgery, Mar 2023 to Jul 2024
- Graduate Research Assistant, Wayne State University, Department of Pharmacology, May 2018 to Dec 2022
- Graduate Teaching Assistant, Wayne State University, Department of Biological Sciences, Aug 2015 to Aug 2017

## Peer-reviewed publications

1. Shahab M, Rosati R, Bhatia P, Doyon-Reale N, Jamesdaniel S. MnTBAP, a peroxynitrite scavenger, attenuates cisplatin-induced apoptosis and cytotoxicity in organ of Corti cells. Toxicology Reports. 2025;14:101967. DOI 10.1016/j.toxrep.2025.101967. PMID 40046635.
2. Shahab M, Rosati R, Stemmer PM, Dombkowski A, Jamesdaniel S. Quantitative profiling of cochlear synaptosomal proteins in cisplatin-induced synaptic dysfunction. Hearing Research. 2024;447:109022. DOI 10.1016/j.heares.2024.109022. PMID 38705005. PMC11116033.
3. Shahab M, Jamesdaniel S. Nitrative stress and auditory dysfunction (review). Pharmaceuticals (Basel). 2022;15(6):649. DOI 10.3390/ph15060649. PMID 35745568.
4. Rosati R, Shahab M, Ramkumar V, Jamesdaniel S. Lmo4 deficiency enhances susceptibility to cisplatin-induced cochlear apoptosis and hearing loss. Molecular Neurobiology. 2021;58(5):2019-2029. DOI 10.1007/s12035-020-02226-4. PMID 33411315.
5. Shahab M, Rosati R, Meyer DN, Shields JN, Crofts E, Baker TR, Jamesdaniel S. Cisplatin-induced hair cell loss in zebrafish neuromasts is accompanied by protein nitration and Lmo4 degradation. Toxicology and Applied Pharmacology. 2021;410:115342. DOI 10.1016/j.taap.2020.115342. PMID 33245977.
6. Rosati R, Shahab M, Neumann WL, Jamesdaniel S. Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells. Experimental Cell Research. 2019;381(1):105-111. DOI 10.1016/j.yexcr.2019.05.008. PMID 31078568.

## Preprints (not peer reviewed)

- Shahab M, Balajee A. Peripheral exercise transcriptomes do not converge on glutamatergic or neuroinflammatory signatures: a cross-platform meta-analysis. bioRxiv, posted November 2, 2026. DOI 10.64898/2026.10.27.762209.
- Shahab M. Preparation composition confounds treatment effects in cochlear synaptosomal proteomics: a nested machine learning reanalysis of cisplatin and MnTBAP exposure. Research Square, posted October 20, 2026. DOI 10.21203/rs.3.rs-11340135/v1. Code: https://github.com/Monazzashahab/cochlear-synaptosome-composition-ml

## Dissertation

- Shahab M. Role of nitrative stress in cisplatin induced ototoxicity and synaptic dysfunction. PhD dissertation, Department of Pharmacology, Wayne State University, 2023. https://digitalcommons.wayne.edu/oa_dissertations/3846/

## Selected results

- Hearing Research 2024: TMTpro LC-MS/MS of mouse cochlear synaptosomes identified 5,225 proteins; 351 changed with cisplatin at a 5% false discovery rate (249 up, 102 down).
- Research Square 2026 (preprint): reanalysis of 4,667 quantified proteins showed preparation composition was confounded with treatment; adjusting for it cut proteins called changed from 15.9% to 6.6%, against 5% expected by chance.
- bioRxiv 2026 (preprint): three GEO datasets, four contrasts in limma, 7,311 unique differentially expressed genes at the discovery threshold; no glutamatergic or neuroinflammatory term reached significance.
- Her doctoral data supported NIH R01 DC020299 (NIDCD), "Targeting nitrative stress for treatment of cisplatin ototoxicity", Wayne State University, project period December 2022 to November 2027. https://reporter.nih.gov/project-details/10587579

## Peer review and service

- Invited peer reviewer: Communications Biology (2025), Scientific Reports (2026), Frontiers in Pharmacology (2026)
- Co-President, University of Michigan Postdoctoral Association (elected December 2024, served January to July 2025; results: https://vote.umich.edu/index.php?mode=results&election=249357)
- Judge and abstract reviewer, Wayne State University School of Medicine (2021 to 2022, 2025)
- Graduate lecturer, University of Michigan, Winter 2025: PHY 610 and PHY 415

## Profiles

- ORCID: https://orcid.org/0000-0002-5134-2233
- LinkedIn: https://www.linkedin.com/in/mskwsu-monazza
- GitHub: https://github.com/Monazzashahab
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Shahab+Monazza%5BAuthor%5D

## Contact and booking

- Book a 20-minute intro call: https://monazzashahab.com/#book
- Email: hello@monazzashahab.com